128. A critical situational publication argues for a new therapy based on a single study with a statistically significant p-value of 0.04. What is the urgency for a biostatistician to advise caution?

  • To immediately adopt the new therapy.
  • To urgently advise that conclusions should not be based on a single study, especially close to the significance threshold, and that replication and meta-analysis are critically important.
  • To ignore all p-values.
  • To assume one study is enough.
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