- To immediately implement the program.
- To urgently explain that for rare diseases, a high positive predictive value (PPV) is difficult to achieve, leading to unnecessary anxiety and follow-up for many healthy individuals.
- To ignore the concept of false positives.
- To use a less sensitive test.
133. A critical situational public health official is considering implementing a widespread screening program for a rare disease. A biostatistician advises that even a highly sensitive and specific test may yield many false positives in this context. What urgency is involved?
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