- To immediately accept the subgroup findings.
- To urgently caution that post-hoc subgroup analyses can lead to spurious findings due to multiple comparisons, requiring independent validation.
- To disregard the main study results.
- To encourage more such analyses.
145. A critical situational research paper makes strong claims about a drug’s effectiveness based on subgroup analyses not specified in the original protocol. What is the urgency for a biostatistician to advise caution?
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