- Increased metabolic rate.
- Decreased production of thyroid hormones, leading to a generalized hypometabolic state.
- Autoimmune destruction of the adrenal glands.
- Excess growth hormone.
18. A patient with untreated hypothyroidism presents with cold intolerance, constipation, fatigue, and bradycardia. What is the technical primary pathophysiological cause of these symptoms?
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