21. A patient with long-standing Type 2 Diabetes Mellitus develops numbness, tingling, and burning pain in his feet. What is the technical primary pathophysiological basis for diabetic neuropathy?

  • Acute inflammation of nerve endings.
  • Demyelination due to autoimmune attack.
  • Microvascular damage and metabolic alterations affecting nerve fibers.
  • Compression of spinal nerves.
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