- Excess cortisol production.
- Autoimmune destruction of the adrenal cortex, leading to deficiency of cortisol and aldosterone.
- Excess aldosterone production.
- Impaired glucose metabolism.
34. A patient with Addison’s disease (adrenal insufficiency) presents with fatigue, weakness, weight loss, and hyperpigmentation. What is the technical primary pathophysiological defect?
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