- Complement activation.
- Autoantibody production.
- Massive release of histamine and other inflammatory mediators from mast cells and basophils.
- T-cell mediated cytotoxicity.
23. A patient with a severe allergic reaction (anaphylaxis) presents with widespread urticaria, angioedema, bronchospasm, and hypotension. What is the technical primary mediator responsible for these symptoms?
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