- Confirm the patient is on the placebo to encourage them to withdraw.
- Suggest the patient discuss their concerns with the principal investigator.
- Tell the patient that they are on the active drug to maintain hope.
- Disclose the blinding status if symptoms worsen further.
A nurse is participating in a research study where patients are blinded to whether they receive the experimental drug or a placebo. A patient in the placebo group experiences worsening symptoms and asks the nurse if they are on the active drug. The nurse knows they are not but is ethically bound by the study protocol to maintain blinding. What is the most ethical response?
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