A nurse is asked to administer an off-label medication to a patient. The nurse researches it and finds limited evidence for its efficacy for the patient’s condition, but potential significant side effects. The physician insists on administering it. What is the nurse’s ethical responsibility?

  • Administer the medication as ordered.
  • Refuse to administer the medication without question.
  • Express concerns to the physician, provide evidence of potential harm or lack of benefit, and seek clarification or an alternative order, escalating if necessary.
  • Administer a reduced dose.
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