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BIO NMDCAT Structure of DNA
nmdcat.online July 3, 2026

100. The structural transition of a specific gene region into a triple-stranded DNA conformation (H-DNA) occurs pathologically within mirror-repeat homopurine-homopyrimidine tracks. The formation of this alternative structure relies on the introduction of non-Watson-Crick hydrogen bonds called

A. Phosphodiester cross-links
B. Hoogsteen base pairs
✓
C. Disulfide bridges
D. Peptide linkages

📝 Explanation

Triple-stranded H-DNA forms when a third single strand winds into the major groove of a duplex, binding via alternative Hoogsteen hydrogen bonds.

📖 Additional Information

  • Phosphodiester cross-links
  • Hoogsteen base pairs
  • Disulfide bridges
  • Peptide linkages

Triple-stranded H-DNA forms when a third single strand winds into the major groove of a duplex, binding via alternative Hoogsteen hydrogen bonds.

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