145. A critical situational research paper makes strong claims about a drug’s effectiveness based on subgroup analyses not specified in the original protocol. What is the urgency for a biostatistician to advise caution?
A.
To immediately accept the subgroup findings.
B.
To urgently caution that post-hoc subgroup analyses can lead to spurious findings due to multiple comparisons, requiring independent validation.
✓
C.
To disregard the main study results.
D.
To encourage more such analyses.
📖 Additional Information
To immediately accept the subgroup findings.
To urgently caution that post-hoc subgroup analyses can lead to spurious findings due to multiple comparisons, requiring independent validation.
