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21. A patient with long-standing Type 2 Diabetes Mellitus develops numbness, tingling, and burning pain in his feet. What is the technical primary pathophysiological basis for diabetic neuropathy?
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23. A patient with a severe allergic reaction (anaphylaxis) presents with widespread urticaria, angioedema, bronchospasm, and hypotension. What is the technical primary mediator responsible for these symptoms?
