28. A patient is prescribed methotrexate for rheumatoid arthritis. Technically, what is the mechanism of action of methotrexate that contributes to its immunosuppressive and anti-inflammatory effects?
A.
Inhibiting TNF-alpha.
B.
Blocking cyclooxygenase enzymes.
C.
Inhibiting dihydrofolate reductase, leading to folate depletion.
✓
D.
Stimulating B-cell proliferation.
📖 Additional Information
Inhibiting TNF-alpha.
Blocking cyclooxygenase enzymes.
Inhibiting dihydrofolate reductase, leading to folate depletion.
