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BIO NMDCAT Cytoplasmic Organelles
nmdcat.online July 4, 2026

38. A block in the budding pathway of COPII vesicles from the endoplasmic reticulum causes a cellular accumulation of

A. Free lipids in the nucleoplasm
B. Newly synthesized proteins inside the ER lumen
✓
C. Lysosomal enzymes in the extracellular matrix
D. Active ribosomes in the peroxisome

📝 Explanation

Because COPII vesicles carry cargo forward (anterograde), blocking them causes proteins to pile up within the ER.

📖 Additional Information

  • Free lipids in the nucleoplasm
  • Newly synthesized proteins inside the ER lumen
  • Lysosomal enzymes in the extracellular matrix
  • Active ribosomes in the peroxisome

Because COPII vesicles carry cargo forward (anterograde), blocking them causes proteins to pile up within the ER.

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