38. A patient on opioid analgesics for chronic pain develops severe constipation. Urgently, which pharmacological class is specifically designed to treat opioid-induced constipation without crossing the blood-brain barrier and reversing analgesia?
A.
Bulk-forming laxatives.
B.
Stool softeners.
C.
Peripherally acting ?-opioid receptor antagonists (PAMORAs, e.g., methylnaltrexone).
