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BIO NMDCAT Ribonucleic acid (RNA)
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98. The architectural arrangement of a eukaryotic gene includes an upstream promoter element. If a chemical agent induces hypermethylation specifically at the cytosine residues of this promoter, the immediate cellular effect is the

A. Generation of truncated, shorter mRNA molecules
B. Silencing of the gene via the inhibition of RNA Polymerase II recruitment
✓
C. Acceleration of alternative splicing events in the cytoplasm
D. Structural deformation of the 28S ribosomal RNA catalytic center

📝 Explanation

Promoter hypermethylation creates a structural barrier that blocks the binding of transcription factors and RNA polymerase, shutting down transcription.

📖 Additional Information

  • Generation of truncated, shorter mRNA molecules
  • Silencing of the gene via the inhibition of RNA Polymerase II recruitment
  • Acceleration of alternative splicing events in the cytoplasm
  • Structural deformation of the 28S ribosomal RNA catalytic center

Promoter hypermethylation creates a structural barrier that blocks the binding of transcription factors and RNA polymerase, shutting down transcription.

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97. A patient presenting with severe microcytic anemia is diagnosed with a form of beta-thalassemia. Molecular sequencing reveals a single nucleotide substitution within an intron of the beta-globin gene that generates a novel, functional 3' splice site. The consequence of this mutation on the resulting mRNA is the

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99. During the process of RNA editing observed in certain eukaryotic transcripts, specific cytidine deaminase enzymes convert targeted cytosine bases into uracil. If this conversion occurs inside a coding exon, it can alter translation by

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