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nmdcat.online June 27, 2026

A mutation in a gene results in a single amino acid substitution in a hemoglobin protein, causing sickle cell anemia. This alteration directly affects the protein’s

A. Primary structure
B. Secondary structure
C. Tertiary structure
D. All of the structural levels mentioned

📝 Explanation

Changing one amino acid (primary structure) can disrupt the local folding (secondary), which in turn alters the overall 3D shape (tertiary) and its ability to bind with other subunits (quaternary). Thus, all higher levels of structure are ultimately dependent on the primary sequence.

📖 Additional Information

  • Primary structure
  • Secondary structure
  • Tertiary structure
  • All of the structural levels mentioned

Changing one amino acid (primary structure) can disrupt the local folding (secondary), which in turn alters the overall 3D shape (tertiary) and its ability to bind with other subunits (quaternary). Thus, all higher levels of structure are ultimately dependent on the primary sequence.

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