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nmdcat.online June 27, 2026

A proenzyme, or zymogen, represents an inactive precursor that is activated by

A. Binding to a competitive inhibitor
B. Denaturation and subsequent renaturation
C. The removal of a specific peptide fragment by proteolysis
✓
D. The reversible binding of a cofactor

📝 Explanation

Zymogens (like pepsinogen to pepsin) are activated by the irreversible hydrolytic cleavage of a portion of their polypeptide chain. This proteolytic cut induces a conformational change that forms the functional active site. This mechanism prevents premature activity in the cell of origin.

📖 Additional Information

  • Binding to a competitive inhibitor
  • Denaturation and subsequent renaturation
  • The removal of a specific peptide fragment by proteolysis
  • The reversible binding of a cofactor

Zymogens (like pepsinogen to pepsin) are activated by the irreversible hydrolytic cleavage of a portion of their polypeptide chain. This proteolytic cut induces a conformational change that forms the functional active site. This mechanism prevents premature activity in the cell of origin.

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