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nmdcat.online June 27, 2026

During the synthesis of a polypeptide chain on a ribosome, the formation of the bond between adjacent amino acids involves a reaction between a growing chain and an incoming

A. tRNA charged with an amino acid at its 3' end
✓
B. mRNA codon at the P site
C. Free amino acid from the cytoplasm
D. Ribosomal RNA in the large subunit

📝 Explanation

The amino acid is covalently attached to the 3' acceptor stem of its cognate tRNA molecule. During elongation, the peptidyl transferase center of the ribosome catalyzes the nucleophilic attack of the amino group of the incoming aminoacyl-tRNA on the ester bond of the peptidyl-tRNA.

📖 Additional Information

  • tRNA charged with an amino acid at its 3' end
  • mRNA codon at the P site
  • Free amino acid from the cytoplasm
  • Ribosomal RNA in the large subunit

The amino acid is covalently attached to the 3' acceptor stem of its cognate tRNA molecule. During elongation, the peptidyl transferase center of the ribosome catalyzes the nucleophilic attack of the amino group of the incoming aminoacyl-tRNA on the ester bond of the peptidyl-tRNA.

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