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nmdcat.online June 27, 2026

In a biochemical pathway, if enzyme 4 is the primary regulatory enzyme, an excess of the final product will most likely cause a decrease in the activity of enzyme 4 through the mechanism of

A. Positive feedback
B. Irreversible inhibition
C. Feedback inhibition or allosteric inhibition
✓
D. Competitive substrate mimicry

📝 Explanation

This is a classic example of feedback inhibition, a negative feedback loop. The final product binds to an allosteric site on enzyme 4 (often the first committed step enzyme), causing a conformational change that reduces its catalytic activity and shuts down the pathway.

📖 Additional Information

  • Positive feedback
  • Irreversible inhibition
  • Feedback inhibition or allosteric inhibition
  • Competitive substrate mimicry

This is a classic example of feedback inhibition, a negative feedback loop. The final product binds to an allosteric site on enzyme 4 (often the first committed step enzyme), causing a conformational change that reduces its catalytic activity and shuts down the pathway.

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