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nmdcat.online June 27, 2026

In the induced fit model, the lowering of a reaction’s activation energy is achieved when the enzyme-substrate complex formation

A. Stresses and bends specific chemical bonds in the substrate
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B. Increases the local concentration of water around the substrate molecule
C. Permanently alters the equilibrium of the reaction toward the products
D. Causes a decrease in the overall temperature of the active site microenvironment

📝 Explanation

The conformational change of the enzyme upon substrate binding physically distorts the substrate molecule. This "strain" on specific bonds makes them less stable and closer to the transition state, thereby reducing the energy required to break them (the activation energy).

📖 Additional Information

  • Stresses and bends specific chemical bonds in the substrate
  • Increases the local concentration of water around the substrate molecule
  • Permanently alters the equilibrium of the reaction toward the products
  • Causes a decrease in the overall temperature of the active site microenvironment

The conformational change of the enzyme upon substrate binding physically distorts the substrate molecule. This "strain" on specific bonds makes them less stable and closer to the transition state, thereby reducing the energy required to break them (the activation energy).

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