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Practice Questions

An increase in parasympathetic nervous system activity will exert significantly different effects on different muscle types. Which of the following correctly describes the expected physiological response?

A. Increased contraction rate of cardiac muscle and relaxation of digestive smooth muscle
B. Decreased contraction rate of cardiac muscle and increased contraction of digestive smooth muscle ✓
C. Relaxation of skeletal muscle and decreased contraction of cardiac muscle
D. Increased contraction of skeletal muscle and relaxation of digestive smooth muscle

The parasympathetic nervous system (via the vagus nerve) slows down the heart rate (cardiac muscle) but stimulates the smooth muscles of the gastrointestinal tract to promote digestion (peristalsis). It has no direct effect on skeletal muscle, which is controlled by the somatic nervous system.

nmdcat.online BIO NMDCAT
Jul 28, 2026

During the physiological response to a sudden drop in environmental temperature, a specific type of muscle tissue contracts rapidly to generate heat. Which structural feature characterizes the cells of this tissue?

A. Unstriated, spindle-shaped cells
B. Multinucleated, unbranched cylindrical cells ✓
C. Uninucleated, branched striated cells
D. Spindle-shaped cells with intercalated discs

Shivering thermogenesis is mediated by skeletal muscles. Skeletal muscle fibers are characterized by being long, cylindrical, unbranched, and multinucleated, with the nuclei located peripherally just beneath the sarcolemma.

nmdcat.online BIO NMDCAT
Jul 28, 2026

Concerning the mechanism of calcium binding during muscle contraction, a key distinction between visceral muscle and voluntary muscle is that visceral muscle:

A. Utilizes troponin C to initiate cross-bridge cycling
B. Relies on calmodulin to activate myosin light-chain kinase ✓
C. Sequesters all its calcium within the rough endoplasmic reticulum
D. Requires ATP for calcium binding rather than cross-bridge detachment

Visceral (smooth) muscle lacks the troponin complex found in skeletal (voluntary) and cardiac muscles. Instead, calcium binds to the regulatory protein calmodulin, which then activates myosin light-chain kinase (MLCK) to phosphorylate myosin and initiate contraction.

nmdcat.online BIO NMDCAT
Jul 28, 2026

A histologist observing a muscle tissue slide notes the presence of centrally located, single nuclei within branched cells that are joined by specialized dark-staining regions. The primary functional significance of these specialized regions is to:

A. Anchor actin filaments during contraction
B. Prevent overstretching of the muscle fibers
C. Allow rapid spread of depolarization between cells ✓
D. Store calcium ions for muscle contraction

The tissue described is cardiac muscle. The specialized dark-staining regions are intercalated discs, which contain gap junctions. These gap junctions allow ions to pass freely between cells, facilitating the rapid spread of depolarization so the heart can contract as a functional syncytium.

nmdcat.online BIO NMDCAT
Jul 28, 2026

Smooth muscle relies heavily on the influx of extracellular calcium for contraction, whereas skeletal muscle relies almost exclusively on intracellular calcium stored in the sarcoplasmic reticulum. Cardiac muscle requires both, but smooth muscle is most immediately affected by the lack of extracellular calcium.

nmdcat.online BIO NMDCAT
Jul 28, 2026

Correct: Cardiac muscle possesses intrinsic rhythmicity and resists fatigue, allowing continuous contraction. A: Skeletal muscle fatigues comparatively quickly. B: Smooth muscle contracts slowly and is not intrinsically rhythmic in the same manner. D: Tendons do not contract. Concept: Functional adaptation of cardiac muscle.

nmdcat.online BIO NMDCAT
Jul 28, 2026

Correct: Skeletal muscles attach to bones and allow voluntary movement. A: Cardiac muscle functions only in the heart. B & D: Smooth (visceral) muscles control internal organs. Concept: Functional classification of muscles.

nmdcat.online BIO NMDCAT
Jul 28, 2026

Compared with skeletal muscle fibers, cardiac muscle fibers are unique because they are:

A. Multinucleated and cylindrical
B. Branched and interconnected ✓
C. Spindle-shaped and non-striated
D. Long and unbranched

Correct: Cardiac muscle fibers branch and connect through intercalated discs. A & D: Describe skeletal muscle. C: Describes smooth muscle. Concept: Structural comparison of muscle tissues.

nmdcat.online BIO NMDCAT
Jul 28, 2026

A patient experiences slow, sustained contractions in the intestine that continue even during sleep. These contractions are produced by:

A. Skeletal muscle
B. Cardiac muscle
C. Smooth muscle ✓
D. Voluntary muscle fibers

Correct: Smooth muscle contracts slowly and involuntarily in the walls of internal organs. A & D: Skeletal muscle is voluntary. B: Cardiac muscle is limited to the heart. Concept: Physiological role of smooth muscle.

nmdcat.online BIO NMDCAT
Jul 28, 2026

Correct: Cardiac muscle is striated and usually has one centrally placed nucleus. A: Smooth muscle lacks striations. B: Skeletal muscle has multiple peripheral nuclei. D: Ligaments are connective tissues. Concept: Microscopic comparison of muscles.

nmdcat.online BIO NMDCAT
Jul 28, 2026

An athlete can consciously stop lifting a weight, but cannot voluntarily stop the heartbeat. This difference exists because cardiac muscle is:

A. Non-living tissue
B. Involuntary in function ✓
C. Non-contractile
D. Attached to bones

Correct: Cardiac muscle contracts involuntarily under the control of the autonomic nervous system and pacemaker cells. A: It is living tissue. C: It contracts continuously. D: It is confined to the heart. Concept: Control of muscle contraction.

nmdcat.online BIO NMDCAT
Jul 28, 2026

Which muscle type is primarily responsible for regulating the diameter of blood vessels?

A. Skeletal muscle
B. Smooth muscle ✓
C. Cardiac muscle
D. Tendon fibers

Correct: Smooth muscle in blood vessel walls controls vasoconstriction and vasodilation. A: Skeletal muscle moves bones. C: Cardiac muscle forms the heart. D: Tendons connect muscles to bones. Concept: Function of smooth muscle.

nmdcat.online BIO NMDCAT
Jul 28, 2026

A histologist observes muscle fibers that branch and are joined end to end by specialized junctions. These fibers belong to:

A. Skeletal muscle
B. Smooth muscle
C. Cardiac muscle ✓
D. Dense connective tissue

Correct: Branched fibers connected by intercalated discs are unique to cardiac muscle. A: Skeletal fibers are long and unbranched. B: Smooth muscle is spindle-shaped. D: Not muscle tissue. Concept: Histology of cardiac muscle.

nmdcat.online BIO NMDCAT
Jul 28, 2026

During vigorous exercise, the muscles that contract voluntarily to move the arms and legs are:

A. Cardiac muscles
B. Smooth muscles
C. Skeletal muscles ✓
D. Visceral muscles

Correct: Skeletal muscles are attached to bones and produce voluntary body movements. A: Cardiac muscle pumps blood. B & D: Smooth (visceral) muscles control internal organs. Concept: Voluntary muscle action.

nmdcat.online BIO NMDCAT
Jul 28, 2026

Correct: Smooth muscle consists of spindle-shaped, non-striated, uninucleate cells found in hollow organs. A: Skeletal muscle is striated and multinucleated. B: Cardiac muscle is branched and found only in the heart. D: Tendons are connective tissue. Concept: Identification of smooth muscle.

nmdcat.online BIO NMDCAT
Jul 28, 2026

Compared with smooth muscle, cardiac muscle is better adapted for continuous rhythmic contractions because it:

A. Lacks mitochondria
B. Possesses intercalated discs and abundant mitochondria ✓
C. Is voluntarily controlled
D. Contains spindle-shaped cells

Correct: Intercalated discs synchronize contraction, while abundant mitochondria provide continuous ATP for rhythmic activity. A: Cardiac muscle is rich in mitochondria. C: It is involuntary. D: Spindle-shaped cells are characteristic of smooth muscle. Concept: Functional adaptations of cardiac muscle.

nmdcat.online BIO NMDCAT
Jul 28, 2026

Correct: Skeletal muscle fibers are multinucleated with peripheral nuclei and visible striations. A: Cardiac muscle has one or two central nuclei. B: Smooth muscle lacks striations. D: Epithelial tissue is not muscle. Concept: Microscopic characteristics of skeletal muscle.

nmdcat.online BIO NMDCAT
Jul 28, 2026

Which muscle type is primarily responsible for maintaining posture and body movement?

A. Smooth muscle
B. Cardiac muscle
C. Skeletal muscle ✓
D. Visceral muscle only

Correct: Skeletal muscles attach to bones and produce voluntary body movements while maintaining posture. A: Smooth muscle controls internal organs. B: Cardiac muscle pumps blood. D: Visceral muscle refers to smooth muscle. Concept: Functional role of skeletal muscle.

nmdcat.online BIO NMDCAT
Jul 28, 2026

A patient loses conscious control of limb movement but heartbeat and intestinal movements continue normally. This observation indicates that cardiac and smooth muscles are primarily:

A. Voluntary tissues
B. Under involuntary control ✓
C. Controlled only by the spinal cord
D. Dependent on skeletal muscles

Correct: Cardiac and smooth muscles function without conscious control. A: Only skeletal muscle is voluntary. C & D: These statements are incorrect. Concept: Voluntary vs. involuntary muscle control.

nmdcat.online BIO NMDCAT
Jul 28, 2026
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