BIO NMDCAT BIOLOGICAL MOLECULES
nmdcat.online June 27, 2026

The double helix of DNA is stabilized by hydrogen bonds between bases, but the primary force driving its formation in water is

A. The hydrophobic interactions between stacked base pairs
B. The strong covalent bonds in the sugar-phosphate backbone
C. The ionic repulsion between the phosphate groups
D. The van der Waals forces between the sugar moieties

📝 Explanation

While hydrogen bonds provide specificity, the planar, non-polar nitrogenous bases "stack" together via hydrophobic interactions to minimize their exposure to water. This base stacking is a major thermodynamic driving force for the stabilization of the DNA double helix.

📖 Additional Information

  • The hydrophobic interactions between stacked base pairs
  • The strong covalent bonds in the sugar-phosphate backbone
  • The ionic repulsion between the phosphate groups
  • The van der Waals forces between the sugar moieties

While hydrogen bonds provide specificity, the planar, non-polar nitrogenous bases "stack" together via hydrophobic interactions to minimize their exposure to water. This base stacking is a major thermodynamic driving force for the stabilization of the DNA double helix.

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