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nmdcat.online June 27, 2026

The irreversible inhibition of the enzyme cyclooxygenase (COX) by aspirin involves the covalent transfer of an acetyl group to a serine residue in the active site. This mechanism is an example of

A. Competitive inhibition
B. Non-competitive inhibition
C. Covalent, irreversible modification
✓
D. Allosteric activation of the enzyme

📝 Explanation

Aspirin (acetylsalicylic acid) acts by transferring its acetyl group to a serine hydroxyl in the active site of COX enzymes. This chemical modification is covalent and permanent (for the life of the enzyme), making it an irreversible inhibition, not a reversible binding interaction.

📖 Additional Information

  • Competitive inhibition
  • Non-competitive inhibition
  • Covalent, irreversible modification
  • Allosteric activation of the enzyme

Aspirin (acetylsalicylic acid) acts by transferring its acetyl group to a serine hydroxyl in the active site of COX enzymes. This chemical modification is covalent and permanent (for the life of the enzyme), making it an irreversible inhibition, not a reversible binding interaction.

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