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BIO NMDCAT Cytoplasmic Organelles
nmdcat.online July 4, 2026

15. The specific mechanical force driving the directional transport of large macromolecular cargos through the nuclear pore complex is provided by the

A. Direct hydrolysis of ATP by the pore scaffold
B. Spatial concentration gradient of Ran-GTP between the nucleus and cytoplasm
✓
C. Electrical charge difference across the envelope
D. Vibrational movement of the nuclear lamina

📝 Explanation

Nuclear transport does not use direct ATP/GTP hydrolysis at the transporter; instead, it relies on high Ran-GTP inside the nucleus and low Ran-GTP in the cytosol to maintain directionality.

📖 Additional Information

  • Direct hydrolysis of ATP by the pore scaffold
  • Spatial concentration gradient of Ran-GTP between the nucleus and cytoplasm
  • Electrical charge difference across the envelope
  • Vibrational movement of the nuclear lamina

Nuclear transport does not use direct ATP/GTP hydrolysis at the transporter; instead, it relies on high Ran-GTP inside the nucleus and low Ran-GTP in the cytosol to maintain directionality.

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