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BIO NMDCAT Cytoplasmic Organelles
nmdcat.online July 4, 2026

14. Experimental inactivation of the Ran-GTPase activating protein (Ran-GAP) inside the cytosol would directly stall nuclear transport by preventing the

A. Phosphorylation of nuclear lamins
B. Hydrolysis of Ran-GTP to Ran-GDP in the cytoplasm
✓
C. Binding of cargo to importin receptors
D. Assembly of nuclear pore glycoproteins

📝 Explanation

Ran-GAP converts Ran-GTP to Ran-GDP in the cytosol, releasing importin to capture new cargo. Without it, the concentration gradient collapses, halting transport.

📖 Additional Information

  • Phosphorylation of nuclear lamins
  • Hydrolysis of Ran-GTP to Ran-GDP in the cytoplasm
  • Binding of cargo to importin receptors
  • Assembly of nuclear pore glycoproteins

Ran-GAP converts Ran-GTP to Ran-GDP in the cytosol, releasing importin to capture new cargo. Without it, the concentration gradient collapses, halting transport.

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