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BIO NMDCAT Cytoplasmic Organelles
nmdcat.online July 4, 2026

36. In cells treated with a drug that selectively blocks the activity of the Sec61 translocon complex, the direct downstream operational failure observed is the

A. Inability to package lipids into transport vesicles
B. Failure of nascent proteins to enter the rough ER lumen
✓
C. Arrest of mRNA export from the nuclear pores
D. Inhibition of ATP synthase assembly in cristae

📝 Explanation

The Sec61 complex forms the physical protein-conducting channel (translocon) across the RER membrane. Blocking it halts co-translational translocation.

📖 Additional Information

  • Inability to package lipids into transport vesicles
  • Failure of nascent proteins to enter the rough ER lumen
  • Arrest of mRNA export from the nuclear pores
  • Inhibition of ATP synthase assembly in cristae

The Sec61 complex forms the physical protein-conducting channel (translocon) across the RER membrane. Blocking it halts co-translational translocation.

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