BIO NMDCAT Cytoplasmic Organelles
nmdcat.online July 4, 2026

35. The molecular chaperone protein BiP assists protein maturation within the rough endoplasmic reticulum lumen by recognizing and binding to

A. Exposed hydrophobic patches on unfolded polypeptides
B. Terminal mannose-6-phosphate residue networks
C. The hydrophilic N-terminal signal sequence
D. O-linked oligosaccharide modifications

📝 Explanation

BiP (Binding Immunoglobulin Protein) uses ATP to mask exposed hydrophobic regions on nascent proteins, preventing aggregation and helping them fold properly.

📖 Additional Information

  • Exposed hydrophobic patches on unfolded polypeptides
  • Terminal mannose-6-phosphate residue networks
  • The hydrophilic N-terminal signal sequence
  • O-linked oligosaccharide modifications

BiP (Binding Immunoglobulin Protein) uses ATP to mask exposed hydrophobic regions on nascent proteins, preventing aggregation and helping them fold properly.

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