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BIO NMDCAT Structure of DNA
nmdcat.online July 3, 2026

89. The introduction of a chemical agent that intercalates flat aromatic rings directly between adjacent base pairs along the DNA double helix disrupts its geometry by increasing the vertical distance between base pairs from 0.34 nm to 0.68 nm. This alteration will directly induce

A. A nonsense mutation via base conversion
B. A frameshift mutation during subsequent DNA replication
✓
C. The automatic removal of all upstream promoter sequences
D. The conversion of the B-DNA template into a single-stranded cistron

📝 Explanation

Intercalating agents distort the helix by stretching the backbone, which tricks DNA polymerase into inserting or omitting bases, causing frameshift mutations.

📖 Additional Information

  • A nonsense mutation via base conversion
  • A frameshift mutation during subsequent DNA replication
  • The automatic removal of all upstream promoter sequences
  • The conversion of the B-DNA template into a single-stranded cistron

Intercalating agents distort the helix by stretching the backbone, which tricks DNA polymerase into inserting or omitting bases, causing frameshift mutations.

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