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BIO NMDCAT Structure of DNA
nmdcat.online July 3, 2026

91. The treatment of a eukaryotic cell line with a specific drug blocks the activity of the enzyme histone deacetylase (HDAC). Biochemically, this inhibition maintains high levels of histone acetylation across the genome, forcing structural genes to remain inside

A. Densely packed heterochromatin, silencing gene expression
B. Open, accessible euchromatin, promoting transcription
✓
C. A single-stranded RNA state that bypasses translation
D. A left-handed Z-DNA configuration that excludes polymerases

📝 Explanation

Inhibiting HDAC keeps histones acetylated, neutralizing their positive charges and keeping chromatin open (euchromatin) to boost transcription.

📖 Additional Information

  • Densely packed heterochromatin, silencing gene expression
  • Open, accessible euchromatin, promoting transcription
  • A single-stranded RNA state that bypasses translation
  • A left-handed Z-DNA configuration that excludes polymerases

Inhibiting HDAC keeps histones acetylated, neutralizing their positive charges and keeping chromatin open (euchromatin) to boost transcription.

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