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BIO NMDCAT Structure of DNA
nmdcat.online July 3, 2026

95. A researcher utilizes a chemical toxin that selectively prevents the hydrolysis of pyrophosphate (PPi​) during nucleic acid synthesis. The immediate impact of this drug on gene replication and transcription is the

A. Acceleration of nucleotide polymerization rates
B. Thermodynamic arrest of phosphodiester bond formation
✓
C. Spontaneous conversion of ribose sugars into deoxyribose variants
D. Uncontrolled duplication of upstream promoter sequences

📝 Explanation

Polymerization relies on the cleavage of pyrophosphate (PPi​→2Pi​) to provide the forward driving force; blocking this halts the reaction.

📖 Additional Information

  • Acceleration of nucleotide polymerization rates
  • Thermodynamic arrest of phosphodiester bond formation
  • Spontaneous conversion of ribose sugars into deoxyribose variants
  • Uncontrolled duplication of upstream promoter sequences

Polymerization relies on the cleavage of pyrophosphate (PPi​→2Pi​) to provide the forward driving force; blocking this halts the reaction.

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