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nmdcat.online June 27, 2026

The addition of a phosphate group to an enzyme, resulting in a conformational change in its active site, is a common mechanism for

A. Irreversible inhibition
B. Competitive inhibition
C. Covalent modification for regulation
✓
D. Permanent denaturation of the enzyme

📝 Explanation

Phosphorylation is a key reversible covalent modification used to regulate enzyme activity. A kinase adds a phosphate group, causing a shape change that can activate or deactivate the enzyme. A phosphatase removes it, reversing the effect.

📖 Additional Information

  • Irreversible inhibition
  • Competitive inhibition
  • Covalent modification for regulation
  • Permanent denaturation of the enzyme

Phosphorylation is a key reversible covalent modification used to regulate enzyme activity. A kinase adds a phosphate group, causing a shape change that can activate or deactivate the enzyme. A phosphatase removes it, reversing the effect.

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