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nmdcat.online July 28, 2026

The physiological response to hypoxia (low oxygen) differs among muscle types. Which muscle type is most susceptible to irreversible damage following a brief period of hypoxia?

A. Multi-unit smooth muscle
B. Single-unit smooth muscle
C. Skeletal muscle
D. Cardiac muscle
✓

📝 Explanation

Cardiac muscle has an absolute requirement for aerobic metabolism to produce ATP. It contains very little glycogen and relies almost entirely on continuous oxygen supply. Skeletal and smooth muscles can rely more heavily on anaerobic glycolysis and can tolerate hypoxia much longer without cell death.

📖 Additional Information

  • Multi-unit smooth muscle
  • Single-unit smooth muscle
  • Skeletal muscle
  • Cardiac muscle

Cardiac muscle has an absolute requirement for aerobic metabolism to produce ATP. It contains very little glycogen and relies almost entirely on continuous oxygen supply. Skeletal and smooth muscles can rely more heavily on anaerobic glycolysis and can tolerate hypoxia much longer without cell death.

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