Practice Questions

70. The biochemical classification of the enzyme horseradish peroxidase, which utilizes a heme group to break down hydrogen peroxide, is a

A. Pure carbohydrate enzyme
B. Conjugated metalloprotein and glycoprotein
C. Nucleoprotein system without metal ions
D. Lipoprotein particle with a lipid core

Horseradish peroxidase is a complex conjugated enzyme; it contains an iron-bearing heme group and carries structural carbohydrate chains.

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69. The structural role of the conjugated molecule known as lipoteichoic acid in Gram-positive bacterial cell walls is to

A. Serve as an alternative genetic template
B. Anchor the peptidoglycan layer to the underlying plasma membrane
C. Catalyze the synthesis of ATP molecules in the periplasm
D. Store excess amino acids during periods of starvation

Lipoteichoic acids span the thick peptidoglycan layer and use their lipid tails to anchor the wall assembly into the cytoplasmic membrane.

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68. The chemical reason why lipids cannot travel freely in blood plasma without being packaged into lipoprotein complexes is their

A. Unusually high molecular weight
B. Hydrophobic nature and total insolubility in aqueous environments
C. High reactivity with circulating oxygen molecules
D. Tendency to undergo spontaneous hydrolysis into glucose

Non-polar triacylglycerols and cholesterol esters aggregate in water; lipoproteins shield them to allow smooth transport through the blood.

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67. The type of conjugated molecule that forms the structural shell (capsid) of many enveloped animal viruses, protecting the genome and aiding entry, is a

A. Purely inorganic crystal layer
B. Viral glycoprotein matrix
C. Sphingolipidic cell wall variant
D. Phosphoprotein template without lipids

Enveloped viruses use host-derived lipids embedded with viral glycoproteins to form a shield that facilitates membrane fusion.

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66. The process of protein quality control in the rough endoplasmic reticulum relies on molecular chaperones recognizing specific

A. Long sequences of purely basic amino acids
B. Terminal glucose residues on the core oligosaccharide of glycoproteins
C. Strands of double-stranded RNA bound to the ribosome
D. Cholesterol molecules embedded in the lumenal membrane

Chaperones like calnexin bind to glycoproteins carrying a single terminal glucose, ensuring the protein folds properly before moving on.

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65. The biochemical feature that determines the density of a lipoprotein particle during ultracentrifugation analysis is the

A. Total number of nitrogenous bases in its core
B. Ratio of dense proteins to low-density lipid components
C. Overall length of its attached carbohydrate chains
D. Concentration of dissolved iron atoms inside its matrix

Proteins are denser than lipids (1.3 g/mL vs. 0.9 g/mL). Particles containing more protein and less lipid exhibit a higher overall density.

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64. The presence of highly sulfated glycosaminoglycan chains in proteoglycans gives these conjugated molecules a dense

A. Net positive charge that attracts anions
B. Net negative charge that binds water and cations
C. Hydrophobic shield that repels all polar substances
D. Covalent affinity for nuclear histone octamers

Sulfated and carboxylated sugars carry negative charges, creating electrostatic fields that draw in water molecules to form a resilient gel.

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63. The function of the non-protein pigment group in the conjugated plant molecule phytochrome is to

A. Dissolve cellular membranes during cell division
B. Absorb specific wavelengths of light to regulate developmental processes
C. Store nitrogen atoms inside vacuolar spaces
D. Transport carbon dioxide from roots to leaves

Phytochrome is a chromoprotein with a light-sensitive bilin prosthetic group that acts as a molecular switch for plant photomorphogenesis.

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62. The molecular structure of collagen found in the extracellular matrix is stabilized by the post-translational addition of hydroxyl groups to proline, a process that requires Vitamin C. Collagen is technically a

A. Glycoprotein containing short glucose and galactose chains
B. Purely hydrophobic lipoprotein without polar groups
C. High-density nucleoprotein complex found in the cytosol
D. Lipopolysaccharide structural variant

Collagen is a structural glycoprotein; its triple-helix structure contains short carbohydrate chains attached to hydroxylysine residues.

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61. The metabolic condition known as Tangier disease is characterized by a severe deficiency in the transport protein ABCA1, leading to the near-total absence of

A. Chylomicrons in the digestive lacteals
B. High-density lipoproteins (HDL) in blood plasma
C. Nucleoproteins inside the nucleolus matrix
D. Glycoproteins on the surface of erythrocytes

ABCA1 is required to load cholesterol onto ApoA-I to form HDL; its absence causes HDL deficiency and lipid buildup in tissues.

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