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BIO NMDCAT Conjugated molecules
nmdcat.online July 3, 2026

61. The metabolic condition known as Tangier disease is characterized by a severe deficiency in the transport protein ABCA1, leading to the near-total absence of

A. Chylomicrons in the digestive lacteals
B. High-density lipoproteins (HDL) in blood plasma
✓
C. Nucleoproteins inside the nucleolus matrix
D. Glycoproteins on the surface of erythrocytes

📝 Explanation

ABCA1 is required to load cholesterol onto ApoA-I to form HDL; its absence causes HDL deficiency and lipid buildup in tissues.

📖 Additional Information

  • Chylomicrons in the digestive lacteals
  • High-density lipoproteins (HDL) in blood plasma
  • Nucleoproteins inside the nucleolus matrix
  • Glycoproteins on the surface of erythrocytes

ABCA1 is required to load cholesterol onto ApoA-I to form HDL; its absence causes HDL deficiency and lipid buildup in tissues.

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