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BIO NMDCAT Conjugated molecules
nmdcat.online July 3, 2026

98. During the assembly of VLDL particles in the liver, the structural protein apolipoprotein B-100 (ApoB-100) must be co-translationally loaded with lipids. This intricate lipid-loading process requires the activity of a specialized chaperone complex known as

A. Ubiquitin ligase
B. Microsomal triglyceride transfer protein (MTP)
✓
C. Hexosaminidase B
D. Peptidyl transferase

📝 Explanation

MTP is essential for transferring lipids onto the emerging ApoB-100 polypeptide chain; a deficiency in MTP results in the disorder abetalipoproteinemia.

📖 Additional Information

  • Ubiquitin ligase
  • Microsomal triglyceride transfer protein (MTP)
  • Hexosaminidase B
  • Peptidyl transferase

MTP is essential for transferring lipids onto the emerging ApoB-100 polypeptide chain; a deficiency in MTP results in the disorder abetalipoproteinemia.

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