nmdcat.online
BIO NMDCAT Conjugated molecules
nmdcat.online July 3, 2026

97. The chemical structure of lipopolysaccharide (LPS) includes the core polysaccharide, the O-antigen, and Lipid A. If a mutant strain of Salmonella synthesizes an altered Lipid A that lacks three of its normal six fatty acid acyl chains, the physiological result is

A. The total inability of the bacteria to divide
B. A massive reduction in its endotoxic potency and structural toll-like receptor 4 (TLR4) activation
✓
C. Spontaneous transformation of the bacteria into a virus
D. Complete loss of its internal ribosomal nucleoproteins

📝 Explanation

The host immune receptor TLR4 identifies the specific configuration of Lipid A's six fatty acid chains; altering this number prevents effective receptor binding and signaling.

📖 Additional Information

  • The total inability of the bacteria to divide
  • A massive reduction in its endotoxic potency and structural toll-like receptor 4 (TLR4) activation
  • Spontaneous transformation of the bacteria into a virus
  • Complete loss of its internal ribosomal nucleoproteins

The host immune receptor TLR4 identifies the specific configuration of Lipid A's six fatty acid chains; altering this number prevents effective receptor binding and signaling.

🔗 Share This Question

Facebook Twitter LinkedIn WhatsApp

🧭 Navigate Questions

Previous Question

96. The architectural layout of the myelin membrane shows an unusually high lipid-to-protein ratio (4:1), containing specific glycolipids like galactocerebrosides. A targeted autoimmune response against these nervous system glycolipids causes

Next Question

98. During the assembly of VLDL particles in the liver, the structural protein apolipoprotein B-100 (ApoB-100) must be co-translationally loaded with lipids. This intricate lipid-loading process requires the activity of a specialized chaperone complex known as

Back to All Questions

🔗 Related MCQs

An increase in the incidence of ectopic pregnancies within a population can often be epidemiologically correlated with a prior increase in the prevalence of which sexually transmitted disease?
July 16, 2026
In the life cycle of Herpes Simplex Virus 2 (HSV-2), the virus travels along nerve fibers to reach the sensory ganglia. The cellular mechanism responsible for this retrograde transport utilizes:
July 16, 2026
A defining characteristic of the lesions associated with the secondary stage of syphilis is that they:
July 16, 2026
The causative agent of genital herpes, HSV-2, is enveloped. The biological significance of this viral envelope in the context of transmission is that it makes the virus:
July 16, 2026
The structural basis for the severe cardiovascular complications seen in tertiary syphilis, such as aortic aneurysms, is the chronic inflammation and destruction of:
July 16, 2026

Categories

View all →