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nmdcat.online July 3, 2026

99. The biochemical characterization of advanced glycation end-products (AGEs), which accumulate pathologically in patients with chronic hyperglycemia, shows they are formed via the

A. Template-directed synthesis of proteins on structural ribosomes
B. Non-enzymatic covalent cross-linking of reducing sugars to proteins or lipids
✓
C. Controlled addition of mannose-6-phosphate inside the Golgi
D. Rapid breakdown of nuclear nucleoproteins during cell division

📝 Explanation

AGEs are formed via glycation, a chaotic, non-enzymatic reaction where excess blood sugars bind randomly to proteins and lipids, disrupting their function.

📖 Additional Information

  • Template-directed synthesis of proteins on structural ribosomes
  • Non-enzymatic covalent cross-linking of reducing sugars to proteins or lipids
  • Controlled addition of mannose-6-phosphate inside the Golgi
  • Rapid breakdown of nuclear nucleoproteins during cell division

AGEs are formed via glycation, a chaotic, non-enzymatic reaction where excess blood sugars bind randomly to proteins and lipids, disrupting their function.

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