MCQs

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Practice Questions

38. A patient on opioid analgesics for chronic pain develops severe constipation. Urgently, which pharmacological class is specifically designed to treat opioid-induced constipation without crossing the blood-brain barrier and reversing analgesia?

A. Bulk-forming laxatives.
B. Stool softeners.
C. Peripherally acting ?-opioid receptor antagonists (PAMORAs, e.g., methylnaltrexone).
D. Stimulant laxatives.
nmdcat.online BS Nursing
Jun 6, 2026

36. A patient is prescribed a macrolide antibiotic (e.g., azithromycin). Technically, what is the mechanism of action of macrolides?

A. Inhibiting bacterial cell wall synthesis.
B. Inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit.
C. Inhibiting bacterial DNA gyrase.
D. Disrupting bacterial cell membrane.
nmdcat.online BS Nursing
Jun 6, 2026

34. A patient develops urgently status epilepticus. Critically, which class of drugs is typically used for initial urgent management to terminate seizures?

A. Phenytoin.
B. Carbamazepine.
C. Benzodiazepines (e.g., lorazepam, diazepam).
D. Ethosuximide.
nmdcat.online BS Nursing
Jun 6, 2026

33. A patient with Type 2 Diabetes is prescribed glipizide. Medicinally, what is the primary mechanism of action of glipizide?

A. Decreasing hepatic glucose production.
B. Increasing glucose uptake in peripheral tissues.
C. Stimulating insulin secretion from pancreatic beta cells.
D. Inhibiting carbohydrate absorption.
nmdcat.online BS Nursing
Jun 6, 2026
nmdcat.online BS Nursing
Jun 6, 2026

31. A patient with chronic heart failure is prescribed carvedilol. Clinically, what is a critical caution when initiating carvedilol therapy, especially in the elderly?

A. Rapid dose escalation is recommended.
B. Initiate at a low dose and titrate up slowly to avoid worsening heart failure symptoms.
C. It should be stopped if blood pressure drops slightly.
D. It should be given only in the hospital setting.
nmdcat.online BS Nursing
Jun 6, 2026

29. A patient with HIV is starting antiretroviral therapy. Medicinally, what is a critical principle of HIV treatment to prevent drug resistance?

A. Monotherapy with the most potent drug.
B. Intermittent therapy to reduce drug burden.
C. Combination therapy with drugs from different classes.
D. High-dose therapy for a short duration.
nmdcat.online BS Nursing
Jun 6, 2026

28. A patient is prescribed methotrexate for rheumatoid arthritis. Technically, what is the mechanism of action of methotrexate that contributes to its immunosuppressive and anti-inflammatory effects?

A. Inhibiting TNF-alpha.
B. Blocking cyclooxygenase enzymes.
C. Inhibiting dihydrofolate reductase, leading to folate depletion.
D. Stimulating B-cell proliferation.
nmdcat.online BS Nursing
Jun 6, 2026

26. A patient is receiving amphotericin B for a severe fungal infection. Urgently, what critical adverse reaction can occur during infusion, necessitating pre-medication and slow infusion?

A. Bradycardia.
B. Infusion-related reactions (e.g., fever, chills, rigors).
C. Severe diarrhea.
D. Hyperglycemia.
nmdcat.online BS Nursing
Jun 6, 2026

25. A patient with deep vein thrombosis is prescribed enoxaparin (a low molecular weight heparin). Medicinally, what is the primary mechanism of action of enoxaparin?

A. Inhibiting vitamin K-dependent clotting factors.
B. Selectively inhibiting Factor Xa.
C. Directly inhibiting thrombin.
D. Activating protein C.
nmdcat.online BS Nursing
Jun 6, 2026
nmdcat.online BS Nursing
Jun 6, 2026

21. A patient with a severe bacterial infection is prescribed gentamicin (an aminoglycoside). Medicinally, what two critical adverse effects require urgent monitoring due to their potential for irreversible damage?

A. Hepatotoxicity and cardiotoxicity.
B. Nephrotoxicity and ototoxicity.
C. Myelosuppression and dermatological reactions.
D. Hyperglycemia and hypokalemia.
nmdcat.online BS Nursing
Jun 6, 2026

20. A patient with peptic ulcer disease is prescribed a proton pump inhibitor (PPI, e.g., omeprazole). Technically, what is the mechanism by which PPIs reduce gastric acid secretion?

A. Blocking histamine H2 receptors.
B. Neutralizing stomach acid.
C. Irreversibly inhibiting the H+/K+-ATPase pump in parietal cells.
D. Coating the stomach lining.
nmdcat.online BS Nursing
Jun 6, 2026
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