BIO NMDCAT Chromosomes

nmdcat.online July 4, 2026

32. The architectural transition of chromatin from a loose beads-on-a-string configuration into a compact 30-nm fiber is directly achieved by the

A. Phosphorylation of core tail histones

B. Coiling of nucleosomes mediated by linker histone H1

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C. Total elimination of non-histone proteins

D. Cleavage of internal phosphodiester loops

📝 Explanation

The structural interaction of linker histone H1 with adjacent nucleosomes drives the further compaction of the 10-nm nucleosome strand into a 30-nm helical spiral loop array termed a solenoid.

📖 Additional Information

Phosphorylation of core tail histones
Coiling of nucleosomes mediated by linker histone H1
Total elimination of non-histone proteins
Cleavage of internal phosphodiester loops

The structural interaction of linker histone H1 with adjacent nucleosomes drives the further compaction of the 10-nm nucleosome strand into a 30-nm helical spiral loop array termed a solenoid.

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