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BIO NMDCAT Conjugated molecules
nmdcat.online July 3, 2026

49. The carbohydrate configuration of the glycoprotein hormone erythropoietin (EPO) is highly critical because its removal results in

A. Spontaneous conversion into an active lipid
B. Immediate clearance and loss of biological activity in vivo
✓
C. The conversion of the hormone into an active enzyme
D. Direct entry of the hormone through the nuclear envelope

📝 Explanation

The oligosaccharide chains on circulating glycoprotein hormones shield them from rapid hepatic filtration and enzymatic degradation.

📖 Additional Information

  • Spontaneous conversion into an active lipid
  • Immediate clearance and loss of biological activity in vivo
  • The conversion of the hormone into an active enzyme
  • Direct entry of the hormone through the nuclear envelope

The oligosaccharide chains on circulating glycoprotein hormones shield them from rapid hepatic filtration and enzymatic degradation.

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