nmdcat.online
BIO NMDCAT Cytoplasmic Organelles
nmdcat.online July 4, 2026

52. A molecular mutation that renders the enzyme phosphotransferase nonfunctional prevents the formation of the M6P tag, leading directly to the clinical manifestation of

A. The accumulation of glycogen in the smooth ER channels
B. The mistargeting and extracellular secretion of lysosomal enzymes
✓
C. The permanent arrest of transport from the rough ER
D. The structural collapse of the nuclear envelope matrix

📝 Explanation

Without the mannose-6-phosphate (M6P) tag, lysosomal enzymes miss their sorting receptors in the trans-Golgi, routing into the default secretory pathway instead (I-cell disease).

📖 Additional Information

  • The accumulation of glycogen in the smooth ER channels
  • The mistargeting and extracellular secretion of lysosomal enzymes
  • The permanent arrest of transport from the rough ER
  • The structural collapse of the nuclear envelope matrix

Without the mannose-6-phosphate (M6P) tag, lysosomal enzymes miss their sorting receptors in the trans-Golgi, routing into the default secretory pathway instead (I-cell disease).

🔗 Share This Question

Facebook Twitter LinkedIn WhatsApp

🧭 Navigate Questions

Previous Question

51. A cellular condition causing loss of structural integrity in the trans-Golgi network would directly impair the transport of

Next Question

53. The precise mechanical mechanism by which COPI-coated vesicles selectively capture escaped ER-resident proteins within the Golgi stack relies on the

Back to All Questions

🔗 Related MCQs

An increase in the incidence of ectopic pregnancies within a population can often be epidemiologically correlated with a prior increase in the prevalence of which sexually transmitted disease?
July 16, 2026
In the life cycle of Herpes Simplex Virus 2 (HSV-2), the virus travels along nerve fibers to reach the sensory ganglia. The cellular mechanism responsible for this retrograde transport utilizes:
July 16, 2026
A defining characteristic of the lesions associated with the secondary stage of syphilis is that they:
July 16, 2026
The causative agent of genital herpes, HSV-2, is enveloped. The biological significance of this viral envelope in the context of transmission is that it makes the virus:
July 16, 2026
The structural basis for the severe cardiovascular complications seen in tertiary syphilis, such as aortic aneurysms, is the chronic inflammation and destruction of:
July 16, 2026

Categories

View all →