BIO NMDCAT Ribonucleic acid (RNA)

nmdcat.online July 3, 2026

65. The biochemical reason why eukaryotic mRNA requires a polyadenylation signal (AAUAAA) is to

A. Attract the small ribosomal subunit to the start site

B. Guide the enzyme complex that cleaves and adds the poly-A tail

✓

C. Block the transcription of structural genes nearby

D. Splice out structural introns efficiently

📝 Explanation

The AAUAAA consensus sequence is recognized by specific endonucleases that cleave the nascent RNA transcript before poly-A polymerase adds the tail.

📖 Additional Information

Attract the small ribosomal subunit to the start site
Guide the enzyme complex that cleaves and adds the poly-A tail
Block the transcription of structural genes nearby
Splice out structural introns efficiently

The AAUAAA consensus sequence is recognized by specific endonucleases that cleave the nascent RNA transcript before poly-A polymerase adds the tail.

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