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BIO NMDCAT Cytoplasmic Organelles
nmdcat.online July 4, 2026

70. Maternal inheritance of mitochondrial genetic disorders occurs because the mammalian zygote selectively eliminates paternal mitochondria through the action of

A. Nuclear exclusion forces during fusion
B. Ubiquitin-dependent autophagic destruction pathways
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C. Immediate osmotic lysis in the fallopian fluid
D. Replication arrest of paternal plasmid molecules

📝 Explanation

Paternal mitochondria entering the egg are tagged with ubiquitin and selectively destroyed via mitophagy, ensuring that only maternal mitochondrial DNA survives.

📖 Additional Information

  • Nuclear exclusion forces during fusion
  • Ubiquitin-dependent autophagic destruction pathways
  • Immediate osmotic lysis in the fallopian fluid
  • Replication arrest of paternal plasmid molecules

Paternal mitochondria entering the egg are tagged with ubiquitin and selectively destroyed via mitophagy, ensuring that only maternal mitochondrial DNA survives.

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