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nmdcat.online July 4, 2026

75. In structural cytology, the target consequence of introducing an artificial molecule that competitively binds to kinetochores is the

A. Inability of spindle microtubules to attach and segregate chromosomes
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B. Complete structural disassembly of the nucleosome octamer cores
C. Spontaneous duplication of telomeric caps without replication loops
D. Hyper-activation of transcription complexes along euchromatin tracks

📝 Explanation

Blocking the kinetochores prevents microtubule attachment at the centromere, interrupting mitotic checkpoints and halting orderly chromosome separation.

📖 Additional Information

  • Inability of spindle microtubules to attach and segregate chromosomes
  • Complete structural disassembly of the nucleosome octamer cores
  • Spontaneous duplication of telomeric caps without replication loops
  • Hyper-activation of transcription complexes along euchromatin tracks

Blocking the kinetochores prevents microtubule attachment at the centromere, interrupting mitotic checkpoints and halting orderly chromosome separation.

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