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BIO NMDCAT Conjugated molecules
nmdcat.online July 3, 2026

79. The biochemical impact of treating a cell with tunicamycin, an antibiotic that completely blocks N-linked glycosylation, is the

A. Total shutdown of nuclear DNA replication
B. Production of misfolded, non-functional secretory and membrane proteins
✓
C. Sudden accumulation of triacylglycerols in mitochondria
D. Immediate conversion of all lipids into carbohydrates

📝 Explanation

Without N-linked oligosaccharide chains, nascent polypeptides inside the ER lumen cannot fold properly, triggering the unfolded protein response.

📖 Additional Information

  • Total shutdown of nuclear DNA replication
  • Production of misfolded, non-functional secretory and membrane proteins
  • Sudden accumulation of triacylglycerols in mitochondria
  • Immediate conversion of all lipids into carbohydrates

Without N-linked oligosaccharide chains, nascent polypeptides inside the ER lumen cannot fold properly, triggering the unfolded protein response.

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