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BIO NMDCAT Ribonucleic acid (RNA)
nmdcat.online July 3, 2026

86. An experimental system containing a mutant eukaryotic cell line fails to process pre-rRNA into mature 18S and 28S ribosomal components. A structural analysis reveals a defect in a class of non-coding RNAs that orchestrate the methylation and cleavage of the primary ribosomal transcript. The group of RNA molecules defective in this cell line is the

A. Small nuclear RNAs (snRNAs)
B. Small nucleolar RNAs (snoRNAs)
✓
C. MicroRNAs (miRNAs)
D. Small interfering RNAs (siRNAs)

📝 Explanation

Small nucleolar RNAs (snoRNAs) reside within the nucleolus and act as guide RNAs that direct the biochemical modification and splicing of pre-rRNA.

📖 Additional Information

  • Small nuclear RNAs (snRNAs)
  • Small nucleolar RNAs (snoRNAs)
  • MicroRNAs (miRNAs)
  • Small interfering RNAs (siRNAs)

Small nucleolar RNAs (snoRNAs) reside within the nucleolus and act as guide RNAs that direct the biochemical modification and splicing of pre-rRNA.

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