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BIO NMDCAT CELL STRUCTURE & FUNCTION
nmdcat.online July 3, 2026

93. An animal cell line is engineered to completely block the expression of the protein vinculin, which is a structural component of focal adhesions. This genetic modification will directly impair the cell’s ability to

A. Form a functional cleavage furrow during mitotic division
B. Adhere to the extracellular matrix and migrate across surfaces
✓
C. Synthesize cholesterol molecules inside the smooth ER
D. Route lysosomal enzymes from the Golgi to the lysosome

📝 Explanation

Vinculin helps anchor internal actin microfilaments to transmembrane integrins, a structural link required for cell-matrix adhesion and motility.

📖 Additional Information

  • Form a functional cleavage furrow during mitotic division
  • Adhere to the extracellular matrix and migrate across surfaces
  • Synthesize cholesterol molecules inside the smooth ER
  • Route lysosomal enzymes from the Golgi to the lysosome

Vinculin helps anchor internal actin microfilaments to transmembrane integrins, a structural link required for cell-matrix adhesion and motility.

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