BIO NMDCAT Conjugated molecules
nmdcat.online July 3, 2026

94. The human immunodeficiency virus (HIV) utilizes its surface glycoprotein gp120 to bind to host cells. This conjugated molecule exhibits a high degree of structural shielding due to dense N-linked glycosylation, which allows the virus to

A. Directly synthesize ATP inside the viral particle
B. Mask its highly conserved protein epitopes from neutralizing host antibodies
C. Replicate its genome without utilizing an RNA intermediate
D. Form covalent cross-links with the host cell wall

📝 Explanation

The dense array of host-derived sugar chains on gp120 creates a structural "glycan shield" that hides underlying viral protein epitopes from the host immune system.

📖 Additional Information

  • Directly synthesize ATP inside the viral particle
  • Mask its highly conserved protein epitopes from neutralizing host antibodies
  • Replicate its genome without utilizing an RNA intermediate
  • Form covalent cross-links with the host cell wall

The dense array of host-derived sugar chains on gp120 creates a structural "glycan shield" that hides underlying viral protein epitopes from the host immune system.

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