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BIO NMDCAT Conjugated molecules
nmdcat.online July 3, 2026

94. The human immunodeficiency virus (HIV) utilizes its surface glycoprotein gp120 to bind to host cells. This conjugated molecule exhibits a high degree of structural shielding due to dense N-linked glycosylation, which allows the virus to

A. Directly synthesize ATP inside the viral particle
B. Mask its highly conserved protein epitopes from neutralizing host antibodies
✓
C. Replicate its genome without utilizing an RNA intermediate
D. Form covalent cross-links with the host cell wall

📝 Explanation

The dense array of host-derived sugar chains on gp120 creates a structural "glycan shield" that hides underlying viral protein epitopes from the host immune system.

📖 Additional Information

  • Directly synthesize ATP inside the viral particle
  • Mask its highly conserved protein epitopes from neutralizing host antibodies
  • Replicate its genome without utilizing an RNA intermediate
  • Form covalent cross-links with the host cell wall

The dense array of host-derived sugar chains on gp120 creates a structural "glycan shield" that hides underlying viral protein epitopes from the host immune system.

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