nmdcat.online
BIO NMDCAT Ribonucleic acid (RNA)
nmdcat.online July 3, 2026

95. A genetic sequence undergoes a mutation that disrupts the conserved branch-point sequence located within an intron of a pre-mRNA molecule. This molecular defect would directly inhibit the

A. Addition of the 7-methylguanosine cap structure
B. Formation of the lariat intermediate during spliceosome-mediated splicing
✓
C. Binding of the transcript to the 16S subunit of the ribosome
D. Export of the mature transcript through the nuclear pore complex

📝 Explanation

The branch-point sequence contains an adenine residue whose 2'-OH attacks the 5' splice site, a critical step for lariat formation during splicing.

📖 Additional Information

  • Addition of the 7-methylguanosine cap structure
  • Formation of the lariat intermediate during spliceosome-mediated splicing
  • Binding of the transcript to the 16S subunit of the ribosome
  • Export of the mature transcript through the nuclear pore complex

The branch-point sequence contains an adenine residue whose 2'-OH attacks the 5' splice site, a critical step for lariat formation during splicing.

🔗 Share This Question

Facebook Twitter LinkedIn WhatsApp

🧭 Navigate Questions

Previous Question

94. In an experimental assay, the introduction of a structural analog that mimics the 3' end of an aminoacyl-tRNA causes premature chain termination during translation by entering the A site and covalently linking to the growing peptide. This compound is

Next Question

96. The replication of the ends of linear eukaryotic chromosomes requires a specialized ribonucleoprotein complex called telomerase. The functional role of the RNA component within telomerase is to

Back to All Questions

🔗 Related MCQs

An increase in the incidence of ectopic pregnancies within a population can often be epidemiologically correlated with a prior increase in the prevalence of which sexually transmitted disease?
July 16, 2026
In the life cycle of Herpes Simplex Virus 2 (HSV-2), the virus travels along nerve fibers to reach the sensory ganglia. The cellular mechanism responsible for this retrograde transport utilizes:
July 16, 2026
A defining characteristic of the lesions associated with the secondary stage of syphilis is that they:
July 16, 2026
The causative agent of genital herpes, HSV-2, is enveloped. The biological significance of this viral envelope in the context of transmission is that it makes the virus:
July 16, 2026
The structural basis for the severe cardiovascular complications seen in tertiary syphilis, such as aortic aneurysms, is the chronic inflammation and destruction of:
July 16, 2026

Categories

View all →